The main risk factor for CSCC development is ultraviolet exposure, which induces DNA damage and leads to a high tumor mutational burden (TMB). 10, 11, 12 Indeed, the rationale for using a PD-1 checkpoint inhibitor in CSCC is strong. Programed cell death 1 (PD-1) immune checkpoint inhibition has been shown to be highly effective in patients with metastatic or advanced CSCC not amenable to curative surgery and/or radiotherapy with response rates ranging 34–50%. 6, 7 Despite aggressive local treatment, approximately 30% of patients with locoregionally advanced, resectable CSCC will recur and eventually die of disease.
4, 5 Standard treatment of resectable locoregionally advanced CSCC is surgery followed by adjuvant radiotherapy, which can cause significant disfigurement and functional morbidity.
3 While most patients present with early-stage, highly curable disease, about 2–5% present with locoregionally advanced CSCC. 2 Because of increasing sun exposure and an aging population, the incidence of CSCC is rising.
The ability to export semi-transparent objects on a graph to PDFĪlso, introducing Prism Labs with the first release from our experimental workshop: explore how Prism can now identify "unstable" parameters in nonlinear regression instead of classifying entire model fits as "ambiguous".Approximately 1,100,000 Americans 1 are diagnosed yearly with cutaneous squamous cell carcinoma (CSCC), with the head and neck (HN) harboring up to 80% of cases. Corrected results for repeated measures Two-way ANOVA when no variation between subjects exists. Expanded results from ordinary Two-way ANOVA, now including a "Data summary" section displaying a number of columns, rows, and values. Improved Results Tabs appearance, increasing visibility and usability. The option to toggle between a "Data with Results" view in the Navigator (data tables and linked results sheets grouped), or separate "Data" and "Results" sections. The ability to add multiple annotations for a single bar (above, within at top, AND within at bottom). The option to set a graph's axis scale to a Natural Log (Ln) scale. New equations in the nonlinear regression equation library: Absolute IC50 and all dose-response equations with X as concentration OR log(concentration). 
Choose from three different styles and set your preferred style as a default
New options for visualizing scatter plots. Introducing new features, performance improvements and bug fixes for Prism 8, including:
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